个人简介：
闫芳芳，1993年生，山东滨州人，副教授。2022年于天津大学获理学博士学位。曾获“山东省优秀学生”、“山东省优秀毕业生”、“国家奖学金（两次）”、“国家励志奖学金”、“天津大学优秀博士论文”等多项荣誉。2023年1月，就职于365be体膏官网。主要从事生物分子结构的量化计算、计算机辅助药物设计、化合物与靶标蛋白互作机制的动力学模拟研究。近5年来，以独立第一作者在Journal of Infection、Briefings in Bioinformatics等期刊上发表SCI研究论文10余篇，累计影响因子127.1。担任Briefings in Bioinformatics、ACS Chemical Neuroscience、Physical Chemistry Chemical Physics等多个知名期刊的审稿人。
主要研究方向：
1.呕吐毒素脱毒酶的分子设计
2.植物广谱抗病机制解析和分子设计
近年来主要代表论文：
1.FangFang Yan, Feng Gao*, RBD-ACE2 binding properties in five SARS-CoV-2 variants of concern with new perspectives in the design of pan-coronavirus peptide inhibitors. Journal of Infection, 2023, 86(2): e51-e54. (IF=38.637)
2. FangFang Yan, Feng Gao*, EK1 with dual Q1004E/N1006I mutation: a promising fusion inhibitor for the HR1 domain of SARS-CoV-2. Journal of Infection, 2022, 84(4): 579-613. (IF=38.637)
3. FangFang Yan, Feng Gao*, Comparison of the binding characteristics of SARS-CoV and SARS-CoV-2 RBDs to ACE2 at different temperatures by MD simulations. Briefings in Bioinformatics, 2021, 22(2): 1122-1136. (IF=13.994，获“人民日报”，“科技日报”，“人民网”，“光明网”，“联合早报”，“鳳凰华人资讯网”，“前瞻网”等海内外多个新闻报道).
4. FangFang Yan, Feng Gao*, An overview of potential inhibitors targeting non-structural proteins 3 (PL pro and Mac1) and 5 (3CL pro /M pro ) of SARS-CoV-2. Computational and structural biotechnology journal, 2021, 19: 4868-4883. (IF=6.155被评为“热点论文”，其被引频次已进入学术领域最优秀的0.1%之列).
5. FangFang Yan, Feng Gao*, A systematic strategy for the investigation of vaccines and drugs targeting bacteria. Computational and Structural Biotechnology Journal, 2020, 18: 1525-1538. (IF=6.155)
6. FangFang Yan, Xinguo Liu*, et al., Molecular dynamics exploration of selectivity of dual inhibitors 5M7, 65X, and 65Z toward fatty acid binding proteins 4 and 5. International Journal of Molecular Sciences, 2018, 19(9): 2496.(IF=6.208)
7. FangFang Yan, Xinguo Liu*, et al., Electrostatic interaction-mediated conformational changes of adipocyte fatty acid binding protein probed by molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics, 2019, 37(14): 3583-3595.(IF=5.235)
8. FangFang Yan, Xinguo Liu*, et al., Computational revelation of binding mechanisms of inhibitors to endcellular protein tyrosine phosphatase 1B using molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 2018, 36(14): 3636-3650.(IF=5.235)
9. FangFang Yan, Xinguo Liu*, et al., Effect of double mutations T790M/L858R on conformation and drug-resistant mechanism of epidermal growth factor receptor explored by molecular dynamics simulations. RSC Advances, 2018, 8(70): 39797-39810. (IF=4.036)
10. FangFang Yan, Xinguo Liu*, et al., Understanding conformational diversity of heat shock protein 90 (HSP90) and binding features of inhibitors to HSP90 via molecular dynamics simulations. Chemical Biology & Drug Design, 2020, 95(1): 87-103. (IF=2.874)
11. FangFang Yan, Xinguo Liu*, et al., Binding difference of inhibitors ACD and TDZ to A-FABP revealed by molecular dynamics simulations. Journal of Atomic and Molecular Sciences, 2017, 8(3): 97-104.
12. Fangfang Yan, Feng Gao*, et al., Subpopulations, binding characteristics of RBD to ACE2 and potential inhibitors of SARS-CoV-2. 全国生物信息学与系统生物学学术大会(遴选报告), 2021.
联系方式：
山东省泰安市岱宗大街61号,我院作物遗传育种系，271018
电子邮箱: yanfangfang1511@163.com
